Chapter 771 Actinomadura R39 d-Ala d Ala Carboxypeptidase

bacterial penicillin-binding proteins and beta-lactamases. Antimicrob. Agents Chemother. 42(1), 1 17. [41] Davies, C., White, S.W., Nicholas, R.A. (2001). Crystal structure of a deacylation-defective mutant of penicillin-binding protein 5 at 2.3-Å resolution. J. Biol. Chem. 276(1), 616 623. [42] Nicola, G., Tomberg, J., Pratt, R.F., Nicholas, R.A., Davies, C. (2010). Crystal structures of covalent complexes of beta-lactam antibiotics with Escherichia coli penicillin-binding protein 5: toward an understanding of antibiotic specificity. Biochemistry 49(37), 8094 8104. [43] Pratt, R.F., McLeish, M.J. (2010). Structural relationship between the active sites of beta-lactam-recognizing and amidase signature enzymes: convergent evolution? Biochemistry 49(45), 9688 9697. [44] Blumberg, P.M., Strominger, J.L. (1972). Isolation by covalent affinity chromatography of the penicillin-binding components from membranes of Bacillus subtilis. Proc. Natl. Acad. Sci. USA 69(12), 3751 3755. [45] Kawai, F., Clarke, T.B., Roper, D.I., Han, G.J., Hwang, K.Y., Unzai, S., Obayashi, E., Park, S.Y., Tame, J.R. (2010). Crystal structures of penicillin-binding proteins 4 and 5 from Haemophilus influenzae. J. Mol. Biol. 396(3), 634 645. [46] Broome-Smith, J.K., Ioannidis, I., Edelman, A., Spratt, B.G. (1988). Nucleotide sequences of the penicillin-binding protein 5 and 6 genes of Escherichia coli. Nucleic Acids Res. 16(4), 1617. [47] Chowdhury, C., Ghosh, A.S. (2011). Differences in active-site microarchitecture explain the dissimilar behaviors of PBP5 and 6 in Escherichia coli. J. Mol. Graph. Model. 29(5), 650 656. [48] Nicola, G., Fedarovich, A., Nicholas, R.A., Davies, C. (2005). A large displacement of the SXN motif of Cys115-modified penicillin-binding protein 5 from Escherichia coli. Biochem. J. 392(Pt. 1), 55 63. [49] Morlot, C., Pernot, L., Le Gouellec, A., Di Guilmi, A.M., Vernet, T., Dideberg, O., Dessen, A. (2005). Crystal structure of a peptidoglycan synthesis regulatory factor (PBP3) from Streptococcus pneumonia. J. Biol. Chem. 280(16), 15984 15991. [50] Pratt, R.F. (2002). Functional evolution of the serine β-lactamase active site. J. Chem. Soc. Perkin Transactions 2(5), 851 861.